Interaction between the three frequently co-occurring Fusarium mycotoxins in rats.
Identifieur interne : 000465 ( Main/Exploration ); précédent : 000464; suivant : 000466Interaction between the three frequently co-occurring Fusarium mycotoxins in rats.
Auteurs : Judit Szab Fodor [Hongrie] ; András Szab [Hongrie] ; Dániel K Cs [Hongrie] ; Kinga Marosi [Hongrie] ; Brigitta B Ta [Hongrie] ; Mariam Kachlek [Hongrie] ; Mikl S Mézes [Hongrie] ; Krisztián Balogh [Hongrie] ; György Kövér [Hongrie] ; István Nagy [Hongrie] ; R Bert Glávits [Hongrie] ; Melinda Kovács [Hongrie]Source :
- Journal of animal physiology and animal nutrition [ 1439-0396 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antioxydants (métabolisme), Foie (anatomopathologie), Foie (effets des médicaments et des substances chimiques), Fusarium (composition chimique), Interactions médicamenteuses (MeSH), Mycotoxines (composition chimique), Mycotoxines (pharmacocinétique), Mycotoxines (toxicité), Mâle (MeSH), Peroxydation lipidique (MeSH), Poids (effets des médicaments et des substances chimiques), Rate (anatomopathologie), Rate (effets des médicaments et des substances chimiques), Rats (MeSH), Rein (anatomopathologie), Rein (effets des médicaments et des substances chimiques), Taille d'organe (MeSH), Test des comètes (MeSH), Tests de toxicité (MeSH).
- MESH :
- anatomopathologie : Foie, Rate, Rein.
- composition chimique : Fusarium, Mycotoxines.
- effets des médicaments et des substances chimiques : Foie, Poids, Rate, Rein.
- métabolisme : Antioxydants.
- pharmacocinétique : Mycotoxines.
- toxicité : Mycotoxines.
- Animaux, Interactions médicamenteuses, Mâle, Peroxydation lipidique, Rats, Taille d'organe, Test des comètes, Tests de toxicité.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (metabolism), Body Weight (drug effects), Comet Assay (MeSH), Drug Interactions (MeSH), Fusarium (chemistry), Kidney (drug effects), Kidney (pathology), Lipid Peroxidation (MeSH), Liver (drug effects), Liver (pathology), Male (MeSH), Mycotoxins (chemistry), Mycotoxins (pharmacokinetics), Mycotoxins (toxicity), Organ Size (MeSH), Rats (MeSH), Spleen (drug effects), Spleen (pathology), Toxicity Tests (MeSH).
- MESH :
- chemical , chemistry : Mycotoxins.
- chemical , metabolism : Antioxidants.
- chemistry : Fusarium.
- drug effects : Body Weight, Kidney, Liver, Spleen.
- pathology : Kidney, Liver, Spleen.
- chemical , pharmacokinetics : Mycotoxins.
- chemical , toxicity : Mycotoxins.
- Animals, Comet Assay, Drug Interactions, Lipid Peroxidation, Male, Organ Size, Rats, Toxicity Tests.
Abstract
To test the complex, acute biochemical effects of combined, naturally co-occurring fusariotoxins, a 5-day rat study was performed. Mycotoxin treatment was invented by intraperitoneal injection: FB1 (F): 9 µg/animal/day (approx. 30 µg/kg bw/day), DON (D): 16.5 µg/animal/day (approx. 55 µg/kg bw/day) and ZEN (Z): 12.75 µg/animal/day (approx. 42.5 µg/kg bw/day). The binary groups (FB1 and DON [FD], FB1 and ZEN [FZ] and DON and ZEN [DZ]) as well as the ternary (FB1 , DON and ZEN [FDZ]) group were dosed at the same combined level as the individual mycotoxins. Body weight, feed intake and mortality were not affected by any of the treatments. FB1 and DON in combination (FD) increased the plasma aspartate aminotransferase activity synergistically (compared to the individual FB1 and DON). In the liver, both the total glutathione (GSH) and the glutathione peroxidase (GPx) activity were increased (p < 0.05) by the binary FB1 and ZEN (FZ) and the DON and ZEN (DZ) groups as well as the ternary FB1 , DON and ZEA group (FDZ) compared to the control. The GSH level of the ternary group was significantly increased compared to the FB1 group, whereas the GPx activity of the ternary group was significantly increased compared to all three the individual mycotoxin groups. The Bliss independence method revealed synergism between DON and ZEN (DZ), as well as FB1 and DON (FD) on liver GPx activity. None of the toxins alone or in combination exerted strong genotoxicity on lymphocytes, neither on the gross histopathological characteristics. However, even at these low levels acute exposure of more than one of these mycotoxins (FB1 , DON and ZEN) affected metabolic and detoxification changes.
DOI: 10.1111/jpn.13013
PubMed: 30362174
Affiliations:
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sortKey="Mezes, Mikl S" sort="Mezes, Mikl S" uniqKey="Mezes M" first="Mikl S" last="Mézes">Mikl S Mézes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő</wicri:regionArea><wicri:noRegion>Gödöllő</wicri:noRegion></affiliation></author><author><name sortKey="Balogh, Krisztian" sort="Balogh, Krisztian" uniqKey="Balogh K" first="Krisztián" last="Balogh">Krisztián Balogh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, 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Szab</name><affiliation wicri:level="1"><nlm:affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author><author><name sortKey="K Cs, Daniel" sort="K Cs, Daniel" uniqKey="K Cs D" first="Dániel" last="K Cs">Dániel K Cs</name><affiliation wicri:level="1"><nlm:affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author><author><name sortKey="Marosi, Kinga" sort="Marosi, Kinga" uniqKey="Marosi K" first="Kinga" last="Marosi">Kinga Marosi</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author><author><name sortKey="B Ta, Brigitta" sort="B Ta, Brigitta" uniqKey="B Ta B" first="Brigitta" last="B Ta">Brigitta B Ta</name><affiliation wicri:level="1"><nlm:affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author><author><name sortKey="Kachlek, Mariam" sort="Kachlek, Mariam" uniqKey="Kachlek M" first="Mariam" last="Kachlek">Mariam Kachlek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author><author><name sortKey="Mezes, Mikl S" sort="Mezes, Mikl S" uniqKey="Mezes M" first="Mikl S" last="Mézes">Mikl S Mézes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő</wicri:regionArea><wicri:noRegion>Gödöllő</wicri:noRegion></affiliation></author><author><name sortKey="Balogh, Krisztian" sort="Balogh, Krisztian" uniqKey="Balogh K" first="Krisztián" last="Balogh">Krisztián Balogh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő</wicri:regionArea><wicri:noRegion>Gödöllő</wicri:noRegion></affiliation></author><author><name sortKey="Kover, Gyorgy" sort="Kover, Gyorgy" uniqKey="Kover G" first="György" last="Kövér">György Kövér</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Economic Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Economic Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author><author><name sortKey="Nagy, Istvan" sort="Nagy, Istvan" uniqKey="Nagy I" first="István" last="Nagy">István Nagy</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author><author><name sortKey="Glavits, R Bert" sort="Glavits, R Bert" uniqKey="Glavits R" first="R Bert" last="Glávits">R Bert Glávits</name><affiliation wicri:level="3"><nlm:affiliation>Autopsy Ltd, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Autopsy Ltd, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Kovacs, Melinda" sort="Kovacs, Melinda" uniqKey="Kovacs M" first="Melinda" last="Kovács">Melinda Kovács</name><affiliation wicri:level="1"><nlm:affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár</wicri:regionArea><wicri:noRegion>Kaposvár</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of animal physiology and animal nutrition</title><idno type="eISSN">1439-0396</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antioxidants (metabolism)</term><term>Body Weight (drug effects)</term><term>Comet Assay (MeSH)</term><term>Drug Interactions (MeSH)</term><term>Fusarium (chemistry)</term><term>Kidney (drug effects)</term><term>Kidney (pathology)</term><term>Lipid Peroxidation (MeSH)</term><term>Liver (drug effects)</term><term>Liver (pathology)</term><term>Male (MeSH)</term><term>Mycotoxins (chemistry)</term><term>Mycotoxins (pharmacokinetics)</term><term>Mycotoxins (toxicity)</term><term>Organ Size (MeSH)</term><term>Rats (MeSH)</term><term>Spleen (drug effects)</term><term>Spleen (pathology)</term><term>Toxicity Tests (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antioxydants (métabolisme)</term><term>Foie (anatomopathologie)</term><term>Foie (effets des médicaments et des substances chimiques)</term><term>Fusarium (composition chimique)</term><term>Interactions médicamenteuses (MeSH)</term><term>Mycotoxines (composition chimique)</term><term>Mycotoxines (pharmacocinétique)</term><term>Mycotoxines (toxicité)</term><term>Mâle (MeSH)</term><term>Peroxydation lipidique (MeSH)</term><term>Poids (effets des médicaments et des substances chimiques)</term><term>Rate (anatomopathologie)</term><term>Rate (effets des médicaments et des substances chimiques)</term><term>Rats (MeSH)</term><term>Rein (anatomopathologie)</term><term>Rein (effets des médicaments et des substances chimiques)</term><term>Taille d'organe (MeSH)</term><term>Test des comètes (MeSH)</term><term>Tests de toxicité (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Mycotoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term><term>Rate</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Fusarium</term><term>Mycotoxines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Body Weight</term><term>Kidney</term><term>Liver</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Foie</term><term>Poids</term><term>Rate</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Kidney</term><term>Liver</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Mycotoxines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Mycotoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Mycotoxins</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Mycotoxines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Comet Assay</term><term>Drug Interactions</term><term>Lipid Peroxidation</term><term>Male</term><term>Organ Size</term><term>Rats</term><term>Toxicity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Interactions médicamenteuses</term><term>Mâle</term><term>Peroxydation lipidique</term><term>Rats</term><term>Taille d'organe</term><term>Test des comètes</term><term>Tests de toxicité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To test the complex, acute biochemical effects of combined, naturally co-occurring fusariotoxins, a 5-day rat study was performed. Mycotoxin treatment was invented by intraperitoneal injection: FB<sub>1</sub> (F): 9 µg/animal/day (approx. 30 µg/kg bw/day), DON (D): 16.5 µg/animal/day (approx. 55 µg/kg bw/day) and ZEN (Z): 12.75 µg/animal/day (approx. 42.5 µg/kg bw/day). The binary groups (FB<sub>1</sub> and DON [FD], FB<sub>1</sub> and ZEN [FZ] and DON and ZEN [DZ]) as well as the ternary (FB<sub>1</sub> , DON and ZEN [FDZ]) group were dosed at the same combined level as the individual mycotoxins. Body weight, feed intake and mortality were not affected by any of the treatments. FB<sub>1</sub> and DON in combination (FD) increased the plasma aspartate aminotransferase activity synergistically (compared to the individual FB<sub>1</sub> and DON). In the liver, both the total glutathione (GSH) and the glutathione peroxidase (GPx) activity were increased (p < 0.05) by the binary FB<sub>1</sub> and ZEN (FZ) and the DON and ZEN (DZ) groups as well as the ternary FB<sub>1</sub> , DON and ZEA group (FDZ) compared to the control. The GSH level of the ternary group was significantly increased compared to the FB<sub>1</sub> group, whereas the GPx activity of the ternary group was significantly increased compared to all three the individual mycotoxin groups. The Bliss independence method revealed synergism between DON and ZEN (DZ), as well as FB<sub>1</sub> and DON (FD) on liver GPx activity. None of the toxins alone or in combination exerted strong genotoxicity on lymphocytes, neither on the gross histopathological characteristics. However, even at these low levels acute exposure of more than one of these mycotoxins (FB<sub>1</sub> , DON and ZEN) affected metabolic and detoxification changes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30362174</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>16</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1439-0396</ISSN><JournalIssue CitedMedium="Internet"><Volume>103</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of animal physiology and animal nutrition</Title><ISOAbbreviation>J Anim Physiol Anim Nutr (Berl)</ISOAbbreviation></Journal><ArticleTitle>Interaction between the three frequently co-occurring Fusarium mycotoxins in rats.</ArticleTitle><Pagination><MedlinePgn>370-382</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jpn.13013</ELocationID><Abstract><AbstractText>To test the complex, acute biochemical effects of combined, naturally co-occurring fusariotoxins, a 5-day rat study was performed. Mycotoxin treatment was invented by intraperitoneal injection: FB<sub>1</sub> (F): 9 µg/animal/day (approx. 30 µg/kg bw/day), DON (D): 16.5 µg/animal/day (approx. 55 µg/kg bw/day) and ZEN (Z): 12.75 µg/animal/day (approx. 42.5 µg/kg bw/day). The binary groups (FB<sub>1</sub> and DON [FD], FB<sub>1</sub> and ZEN [FZ] and DON and ZEN [DZ]) as well as the ternary (FB<sub>1</sub> , DON and ZEN [FDZ]) group were dosed at the same combined level as the individual mycotoxins. Body weight, feed intake and mortality were not affected by any of the treatments. FB<sub>1</sub> and DON in combination (FD) increased the plasma aspartate aminotransferase activity synergistically (compared to the individual FB<sub>1</sub> and DON). In the liver, both the total glutathione (GSH) and the glutathione peroxidase (GPx) activity were increased (p < 0.05) by the binary FB<sub>1</sub> and ZEN (FZ) and the DON and ZEN (DZ) groups as well as the ternary FB<sub>1</sub> , DON and ZEA group (FDZ) compared to the control. The GSH level of the ternary group was significantly increased compared to the FB<sub>1</sub> group, whereas the GPx activity of the ternary group was significantly increased compared to all three the individual mycotoxin groups. The Bliss independence method revealed synergism between DON and ZEN (DZ), as well as FB<sub>1</sub> and DON (FD) on liver GPx activity. None of the toxins alone or in combination exerted strong genotoxicity on lymphocytes, neither on the gross histopathological characteristics. However, even at these low levels acute exposure of more than one of these mycotoxins (FB<sub>1</sub> , DON and ZEN) affected metabolic and detoxification changes.</AbstractText><CopyrightInformation>© 2018 Blackwell Verlag GmbH.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Szabó-Fodor</LastName><ForeName>Judit</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szabó</LastName><ForeName>András</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kócsó</LastName><ForeName>Dániel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marosi</LastName><ForeName>Kinga</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bóta</LastName><ForeName>Brigitta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kachlek</LastName><ForeName>Mariam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mézes</LastName><ForeName>Miklós</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2323-833X</Identifier><AffiliationInfo><Affiliation>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balogh</LastName><ForeName>Krisztián</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Faculty of Agricultural and Environmental Sciences, Szent István University, Gödöllő, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kövér</LastName><ForeName>György</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Faculty of Economic Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagy</LastName><ForeName>István</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glávits</LastName><ForeName>Róbert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Autopsy Ltd, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kovács</LastName><ForeName>Melinda</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5988-3934</Identifier><AffiliationInfo><Affiliation>MTA-KE Mycotoxins in the Food Chain Research Group, Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Agricultural and Environmental Sciences, Kaposvár University, Kaposvár, Hungary.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>EFOP-3.6.3-VEKOP-16-2017-00005</GrantID><Agency>European Union and the European Social Fund</Agency><Country></Country></Grant><Grant><GrantID>GINOP-2.2.1-15-2016-00021</GrantID><Agency>NRDIO</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>10</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Anim Physiol Anim Nutr (Berl)</MedlineTA><NlmUniqueID>101126979</NlmUniqueID><ISSNLinking>0931-2439</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009183">Mycotoxins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001835" MajorTopicYN="N">Body Weight</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020552" MajorTopicYN="N">Comet Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004347" MajorTopicYN="N">Drug Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005670" MajorTopicYN="N">Fusarium</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009183" MajorTopicYN="N">Mycotoxins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009929" MajorTopicYN="N">Organ Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018675" MajorTopicYN="N">Toxicity Tests</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">deoxynivalenol</Keyword><Keyword MajorTopicYN="N">fumonisin</Keyword><Keyword MajorTopicYN="N">interaction</Keyword><Keyword MajorTopicYN="N">rat</Keyword><Keyword MajorTopicYN="N">zearalenone</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>09</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>10</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>10</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30362174</ArticleId><ArticleId IdType="doi">10.1111/jpn.13013</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Hongrie</li></country><region><li>Hongrie centrale</li></region><settlement><li>Budapest</li></settlement></list><tree><country name="Hongrie"><noRegion><name sortKey="Szab Fodor, Judit" sort="Szab Fodor, Judit" uniqKey="Szab Fodor J" first="Judit" last="Szab Fodor">Judit Szab Fodor</name></noRegion><name sortKey="B Ta, Brigitta" sort="B Ta, Brigitta" uniqKey="B Ta B" first="Brigitta" last="B Ta">Brigitta B Ta</name><name sortKey="Balogh, Krisztian" sort="Balogh, Krisztian" uniqKey="Balogh K" first="Krisztián" last="Balogh">Krisztián Balogh</name><name sortKey="Glavits, R Bert" sort="Glavits, R Bert" uniqKey="Glavits R" first="R Bert" last="Glávits">R Bert Glávits</name><name sortKey="K Cs, Daniel" sort="K Cs, Daniel" uniqKey="K Cs D" first="Dániel" last="K Cs">Dániel K Cs</name><name sortKey="Kachlek, Mariam" sort="Kachlek, Mariam" uniqKey="Kachlek M" first="Mariam" last="Kachlek">Mariam Kachlek</name><name sortKey="Kovacs, Melinda" sort="Kovacs, Melinda" uniqKey="Kovacs M" first="Melinda" last="Kovács">Melinda Kovács</name><name sortKey="Kovacs, Melinda" sort="Kovacs, Melinda" uniqKey="Kovacs M" first="Melinda" last="Kovács">Melinda Kovács</name><name sortKey="Kover, Gyorgy" sort="Kover, Gyorgy" uniqKey="Kover G" first="György" last="Kövér">György Kövér</name><name sortKey="Marosi, Kinga" sort="Marosi, Kinga" uniqKey="Marosi K" first="Kinga" last="Marosi">Kinga Marosi</name><name sortKey="Mezes, Mikl S" sort="Mezes, Mikl S" uniqKey="Mezes M" first="Mikl S" last="Mézes">Mikl S Mézes</name><name sortKey="Nagy, Istvan" sort="Nagy, Istvan" uniqKey="Nagy I" first="István" last="Nagy">István Nagy</name><name sortKey="Szab, Andras" sort="Szab, Andras" uniqKey="Szab A" first="András" last="Szab">András Szab</name><name sortKey="Szab, Andras" sort="Szab, Andras" uniqKey="Szab A" first="András" last="Szab">András 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